BP_blog
Stem Cell Breakthrough

A Scientific and Ethical Leap Forward



Scientific research can be pro-life, and the newest Nobel Prize recipient has proved it. Stay tuned to BreakPoint.

Listen Now | Download


Eric MetaxasThirteen years ago, Dr. Shinya Yamanaka, a Japanese pharmacologist and researcher, made a social call to a friend’s fertility clinic. His friend invited him to look at some human embryos through a microscope.

What Yamanaka saw set him on a path that culminated in a Nobel Prize for Medicine and Physiology. And in the process has won him praise from the pro-life community.

As Yamanaka later told the “New York Times,” “when I saw the embryo, I suddenly realized there was such a small difference between it and my daughters . . . I thought, we can’t keep destroying embryos for our research. There must be another way.”

The search for “another way” took eight years, but eventually Yamanaka and his colleagues at Kyoto University discovered a way to turn “adult skin cells into the equivalent of human embryonic stem cells without using an actual embryo.”

Using methods first developed with laboratory mice, Yamanaka and company “reprogrammed” the adult skin cells by adding “genes called master regulators to the skin cells’ chromosomes. These genes can change the cell’s behavior by turning other genes on and off.”

When the findings were announced five years ago, the moral implications were, if anything, even clearer than the scientific ones. The “New York Times,” in a bit of understatement, said that his research offered a “possible way around the thorny moral issues that have slowed the study of stem cells.” What the Times thought about the destruction of embryos was, of course, left unsaid.

Others were not as reticent: the Vatican followed his work closely and publicized it. Cardinal Justin Rigali, the chairman of the Vatican’s Pro-Life Committee, preached a homily in which he told the story of Yamanaka peering into the microscope. According to Rigali, “God can use a helpless embryo to change a human heart.” The National Right to Life Committee urged that Yamanaka be awarded the Nobel Prize.

Between 2009 and 2012, Yamanaka won three prestigious scientific prizes. Each of them cited the ethical, as well as scientific, impact of his work.

Then on October 8, he won the “big one,” the Nobel Prize for Physiology and Medicine, which he shares with John Gurdon of Great Britain.

As William Saletan of Slate magazine pointed out, the announcement completely omitted any reference to the moral and ethical implications of Yamanaka’s work. They merely cited him for developing “new tools” with which to fight diseases.

As Saletan also noted, much of the mainstream media followed the Nobel committee’s leading: the “New York Times,” which commented, albeit somewhat begrudgingly, on the implications five years ago, completely omitted any such reference this time.

If I were of a more suspicious bent, I might suspect that some people would rather ignore the obvious, and look silly in the process, than acknowledge that pro-life objections to embryonic stem-cell research stand on firm scientific, as well as moral, grounds.

Even when the Nobel Laureate himself has acknowledged the moral considerations that motivated the research, they insist on ignoring the connection.

Well, consider this a shout from the housetops: Saletan is right when he says that Yamanaka deserves an additional Nobel in ethics for tearing “down the wall between preserving embryos and saving lives.”

Further Reading and Information

The Healer
William Saletan | Slate.com | October 9, 2012

Risk Taking Is in His Genes
Martin Fackler | New York Times | December 11, 2007


Comments:

I understand that IPS cells are not absolutely equivalent to embryonic stem cells. However, it is also my understanding that if the nucleus of an IPS cell were transferred to an enucleated egg, it would develop into a human being (a clone). Is the necessity of this extra step (nuclear transfer) sufficient to make the creation and destruction of these cells morally permissible? It seems like these are questions which are at least worth asking when the stakes are so high, and that we should err on the side of life when we don't have concrete answers. Still, I'm asking because I really want to know the answer, not because I have it all figured out. I would welcome further instruction!
Induced pluripotent stem (IPS) cells are not truly equivalent to embryonic stem cells. They are adult cells that are treated in such a way so as to revert back to an embryonic state. However, they do not develop into an embryo. If they did, that would be tantamount to human cloning. The earliest research into stem cells used embryonic stem cells and required the destruction of a human embryo to obtain these cells. The whole embryo is required to become a human being and scientists were essentially parting it out cell by cell to culture stem cells. Yamanaka's research sought to get around this problem by turning on the right genes (which get silenced after the embryonic stage while the baby is developing) to get adult cells (not even adult stem cells, mind you, but differentiated adult cells) to revert back to a pluripotent "embryonic" stage. But again, they cannot become a human embryo by themselves. As a research scientist myself and also a Christian, this is a very big deal, because it essentially makes obsolete the need to destroy embryos to obtain pluripotent stem cells. Now, if anyone declares that they MUST do research by destroying embryos, it's clear that they have some other ulterior motive.
Richard,
The difference between a destroying embryonic cells and adult cells is not primarily a physical one, but a moral one. To destroy one part of one organism, is a very different thing than to destroy the totality of another organism. An adult stem cell is not an individual human, but a very small part of a human, which can be replaced without destroying or even significantly damaging a human. The value of a fertilized embryo is not only in what it can become, but in what it actually is - a complete human being in its earliest stages of development. Now if you believe that all human beings are is matter, organized together into a big randomly created machine, you do have an ethical problem here, because, in that case, human life really doesn't have any intrinsic value at all, adult or child. Even people who contribute to society, are really just contributing to random matter. But if you believe that human beings are intrinsically worth something, then they will also be worth something even in their earliest stages of development.
If adult skin cells are turned "into the equivalent of embryonic stem cells," then why is destroying these cells for the sake of research morally different than destroying an embryo? If they truly are equivalent (and my understanding is that they are), the induced pluripotent stem cells could potentially develop into a human being; they have all the potential that a fertilized egg has. If a fertilized egg is a person, why is one of these "equivalent" cells not a person?